Lipid dynamics in raft domains and effect of an oxidized bilayer component on their formation

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Forsyth, Victor, Ahmadi, Delaram, Thompson, Katherine, Garcia Sakai, Victoria, Schweins, Ralf, Moulin, Martine, Haertlein, Michael, Strohmeier, Gernot. A, Pichler, Harald, Barlow, David J, Lawrence, M. Jayne and Foglia, Fabrizia (2022) Lipid dynamics in raft domains and effect of an oxidized bilayer component on their formation.
Lipid oxidation is linked to many adverse health effects. In this proposal we will use QENS in combination with contrast variation as a non-invasive method to detect and characterize the presence and size of microdomains formed in vesicles of biologically relevant lipids as a function of oxidized lipid levels and temperature. The domain forming lipid mixture system to be used in the present study will be composed of a saturated phospholipid, DPPC, an unsaturated phospholipid, POPC, and cholesterol (Chol) where a portion of the POPC is systematically replaced with the oxidized version of POPC, POnPC.
Research / Data Type: Other
Creators:
Creators
Email
ORCID
Forsyth, Victor
v.t.forsyth@keele.ac.uk
ORCID logohttps://orcid.org/0000-0003-0380-3477
Ahmadi, Delaram
UNSPECIFIED
UNSPECIFIED
Thompson, Katherine
UNSPECIFIED
UNSPECIFIED
Garcia Sakai, Victoria
UNSPECIFIED
UNSPECIFIED
Schweins, Ralf
UNSPECIFIED
UNSPECIFIED
Moulin, Martine
UNSPECIFIED
UNSPECIFIED
Haertlein, Michael
UNSPECIFIED
UNSPECIFIED
Strohmeier, Gernot. A
UNSPECIFIED
UNSPECIFIED
Pichler, Harald
UNSPECIFIED
UNSPECIFIED
Barlow, David J
UNSPECIFIED
UNSPECIFIED
Lawrence, M. Jayne
UNSPECIFIED
UNSPECIFIED
Foglia, Fabrizia
UNSPECIFIED
UNSPECIFIED
Divisions: Faculty of Medicine and Health Sciences > School of Pharmacy and Bioengineering
Collection period:
From
To
29 Nov 2017
1 Jan 2020
Date: 27 Apr 2022
Date type: Publication
Data collection method: RAW data collected at the facility during an experiment.
Additional information: Data Citation The recommended format for citing this dataset in a research publication is as: [author], [date], [title], [publisher], [doi] For Example: Dr Fabrizia Foglia et al; (2017): Lipid dynamics in raft domains and effect of an oxidized bilayer component on their formation , STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1720338
Keywords: QENS, SANS, lipid rafts, lipid, multi-component systems
Is the data in its original format?: Don't know
Status: Published
Publisher: Frontiers in Physics
Copyright holders: Ahmadi, Thompson, García Sakai, Schweins, Moulin, Haertlein, Strohmeier, Pichler, Forsyth, Barlow, Lawrence and Foglia
Contact email address: research.openaccess@keele.ac.uk
DOI: doi.org/10.5286/ISIS.E.RB1720338
Depositing User: Hannah De'Bell
Date Deposited: 21 Jun 2022 09:12
Revision: 13
Last Modified: 21 Jun 2022 09:12

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Frontiers in Physics
- Frontiers in Physics
Resource Title:Frontiers in Physics
Resource Type:Publication
Resource Identifier:http://doi.org/10.3389/fphy.2022.864746
Identifier Type:DOI
URL:https://www.frontiersin.org/articles/10.3389/fphy.2022.864746/full#h6